De nombreux joueurs originaires du Québec ont évolué dans le baseball majeur au fil du temps.
Several players of Quebec origins have made it to the majors through the years.
- Eugène Vadeboncoeur – 1884
- Samuel Larocque – 1888
- Fred Desmarais – 1890
- Pete Lépine – 1902
- Ed Larivière – 1920
- Gus Dugas – 1930
- Joe Krakauskas – 1937
- Sherry Robertson -1940
- Paul Calvert – 1942
- Roland Gladu – 1944
- Jean-Pierre Roy – 1945
- Claude Raymond – 1959
- Georges Maranda – 1960
- Ron Piché – 1960
- Tim Harkness – 1961
- Pete Ward – 1962
- Raymond Daviault – 1962
- Dick Lines – 1965
- Paul Hodgson – 1980
- Denis Boucher – 1991
- Derek Aucoin – 1996
- Éric Gagné – 1999
- Steve Green – 2001
- Éric Cyr – 2002
- Pierre-Luc Laforest – 2003
- Russell Martin – 2005
- Luke Carlin – 2006
- Christopher Leroux – 2009
- Maxim St-Pierre – 2010
- Philippe Aumont – 2012
- Oscar Taveras – 2014
- Jesen Therrien – 2017